Stabilize: MCAS Panel (Quest)

What this panel includes

• Plasma histamine: Measures circulating histamine levels, which are often elevated during a mast cell activation episode

• Tryptase: The primary clinical marker of mast cell activity; elevated levels can indicate mast cell activation or overload

• Homocysteine: Reflects methylation capacity, which influences how efficiently the body breaks down and clears histamine

Biomarkers tested

Why patients choose this

• Insight into mast cell activity and how efficiently the body processes and clears histamine.
• Helpful for those with recurring, seemingly unexplained allergic-type reactions, flushing, or GI symptoms.
• Evaluates plasma histamine, tryptase, and homocysteine together for a fuller picture of mast cell and histamine activity.
• Appropriate for those exploring whether mast cell activation syndrome (MCAS) or histamine intolerance may be contributing to their symptoms.
• Schedule your lab test seamlessly and complete it at a lab near you.

Before your test

Important information

Why it matters: mast cells are part of the immune system, and when they become overactive or release excessive histamine, it can trigger symptoms including flushing, hives, itching, GI discomfort, brain fog, and dizziness.

Who it's for: appropriate for those with recurring unexplained allergic-type reactions, flushing, or GI symptoms, or anyone exploring whether MCAS or histamine intolerance may be involved.

This panel offers insight into mast cell and histamine activity but does not on its own diagnose MCAS; results are interpreted by a clinician alongside your symptoms and history.