Required: Men’s TRT Initial Panel (Bioreference)

What this panel includes

• Comprehensive metabolic panel (CMP): Includes fasting glucose and markers of liver, kidney, and electrolyte balance

• CBC with differential: Offers context on overall health and inflammatory or physiologic stress

• Total testosterone: Measures overall testosterone levels

• Free testosterone: Assesses biologically active testosterone

• Estradiol: Evaluates estrogen balance and conversion, which can influence symptoms and treatment response

• Luteinizing hormone (LH) and follicle stimulating hormone (FSH): Assess pituitary signaling to the testes

• Thyroid function: TSH and free T4 to assess metabolic regulation

• Prolactin: Assesses for hormonal influences that may suppress testosterone

• Total + Free prostate specific antigen (PSA): Screens prostate health for men

• Sex Hormone-Binding Globulin (SHBG): Assesses biologically active hormone levels

• Adrenal and stress hormones: Cortisol (AM) serum to evaluate stress response patterns

• Androgen support: DHEA-S as a marker of adrenal reserve and resilience

• Ferritin: Reflects iron storage and acts as an acute phase reactant in inflammatory states

Biomarkers tested

Why patients choose this

• One comprehensive draw that looks at testosterone, pituitary signaling, thyroid, prostate, and key safety markers, everything needed to start therapy safely.
• Required within six months before starting testosterone therapy (testosterone injections, cream, hCG, and enclomiphene) to evaluate eligibility.
• A discounted, bundled panel rather than paying for each test separately.
• Schedule your lab test seamlessly and complete it at a lab near you.
• Results flow straight into your portal, giving your clinician the full picture to determine whether therapy is appropriate for you.

Before your test

For accurate assessment, this lab panel must be completed between 7:00 and 9:00 a.m., when testosterone levels are at their physiologic peak. Tests drawn outside this window cannot be considered valid for treatment qualification.

It is recommended to fast for at least 8 hours before.

Important information

Why it matters: testosterone therapy requires careful baseline assessment to confirm it's appropriate, effective, and safe before you start.

When: required within six months prior to starting testosterone therapy (injections, cream, hCG, or enclomiphene).

How it's used: these values give your clinician the clinical context to evaluate eligibility and shape your treatment plan.