Estradiol (Topical, Cream)

What it may help with

What's included

• Evaluation and prescription by a licensed clinician, when appropriate
• Estradiol cream compounded by a state-licensed pharmacy
• 2-day, discreet monthly shipping
• Ongoing access to a board-certified clinical team for questions and dose adjustments
• The ability to pause, delay, or cancel your subscription at any time

Why patients choose this

• A daily routine applied wherever fits your lifestyle
• No patch to wear, replace, or worry about adhesion
• A good option for patients who experienced skin irritation from patches
• Dose can be customized in small increments under clinician guidance

Your timeline

1. TodayPlace your order and complete medical intake form.
2. Days 1-2Clinical team reviews in 1-2 business days, and when appropriate, prescribes.
3. Days 3-5Pharmacy prepares your order.
4. Days 5-7Your order ships directly to you with 2-day shipping.
5. Every 4 weeksYour order renews. Payment is processed and the product shipped to you.

What to expect

1. Getting startedApply a small measured amount to clean, dry skin once daily, per your clinician's instructions. Let it fully absorb before dressing or skin-to-skin contact.
2. Weeks 1–2Some women notice early relief from hot flashes and night sweats as levels begin to stabilize.
3. Weeks 2–4Sleep and mood often start to feel steadier as symptom relief builds.
4. Months 2–3Fuller benefit typically settles in here, including relief from vaginal dryness and discomfort. Your dose may be adjusted along the way.
5. OngoingBenefits are maintained with steady daily use. Your clinician reviews how you're responding and adjusts your dose over time.

Lab work requirement

No lab work required. The Women's Comprehensive Panel or Women's Hormonal Health Panel are optional labs to monitor progress if desired.

Possible side effects

Important information

A note on progesterone

If you have an intact uterus, progesterone is typically taken alongside estradiol to help protect the uterine lining. Many patients without a uterus also choose to add progesterone for its potential sleep and mood benefits. Progesterone is available as a separate product in our catalog, and your clinician will review whether it's appropriate for you as part of your medical intake.

A note on application

Apply to clean, dry skin and let the cream fully absorb before dressing or touching others. Avoid skin-to-skin contact at the application site with partners or children until the cream is fully absorbed, as estradiol can transfer through skin contact. Your clinician and care team can answer any questions about safe application.

• Estradiol cream is a prescription medication and requires evaluation by a licensed clinician.

• This medication is compounded, meaning it's custom-prepared by a state-licensed pharmacy based on your clinician's prescription. Compounded estradiol cream is not FDA-approved as a finished drug product. FDA-approved branded topical estradiol products are available; your clinician can discuss whether a compounded or branded option fits your needs.

• Hormone therapy isn't right for everyone. Your clinician will review your medical history, possible side effects, and whether this treatment is right for you.

• Patients with an intact uterus typically take progesterone alongside estradiol. Progesterone is available as a separate product, and your clinician will review whether it's appropriate for you.

• Results vary and are not guaranteed.